No pre-treatment of the powder blends by wet or dry granulation is involved (5). sodium chloride, potassium chloride, potassium bromide, etc.) into a compact form without the addition of other substances.Ĭurrent usage of the term 'direct compression' is used to define the process by which tablets are compressed directly from the powder blends of active ingredient/s and suitable excipients. Previously, the word 'direct compression' was used to identify the compression of a single crystalline compound (i.e. Only 1.7% of the respondents indicated that they never used direct compression and 15.5% indicated that the process was not recommended. About 41% of the companies indicated that direct compression was the method of choice, and 41.1% indicated that they used both direct compression and wet granulation. Of the five processes listed in the survey, the average score (1.0 being the perfect score) for direct compression was 1.5 compared to wet massing and fluid bed drying (2.0), wet massing and tray drying (2.5), all-in-one (3.3) and roller compaction (3.6). The results were in favour of direct compression. Shangraw (6) conducted a survey of 58 products in United States of America for the preference for the granulation process. In early 1960's, the introduction of spray-dried lactose (1960) and Avicel (1964) had changed the tablet manufacturing process and opened avenues of direct compression tableting. The availability of new materials, new forms of old materials and the invention of new machinery has allowed the production of tablets by simplified and reliable methods (1). A great deal of attention has been given to both product and process development in the recent years. Prior to the late 1950s, the literature contained few references on the direct compression of pharmaceuticals. The pros and cons of wet granulation and roller compaction are well documented in the literature (3, 4, 5). wet granulation, roller compaction and direct compression. Experts in the art of tableting are aware with the basic art of tableting by the three well-known methods, i.e. The ease of manufacturing, convenience in administration, accurate dosing, and stability compared to oral liquids, tamper-proofness compared to capsules, safe compared to parental dosage forms makes it a popular and versatile dosage form. The development in the field of APIs, excipients and tableting machines during the past decades has made tablet manufacturing a science and the tablets the most commonly used dosage form ( 1, 2). Over the past hundred years tablet manufacturers have developed materials and processes that can produce compressed tablets containing a precise amount of an active pharmaceutical ingredient (API) at high speed and at relatively low cost. Properties of the co-processed directly compressible adjuvants available Is cost effective and can be prepared in-house based on theįunctionality required. Method for the preparation of directly compressible adjuvants because it The co-processing is the most widely explored The functionality of the directly compressible adjuvants in theįormulation of tablets. The present review outlines the importance of

Direct compression is the preferred method for the

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